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DRUG INTERACTIONS There is inadequate systematic experience with the use of LIORESAL INTRATHECAL in combination with other medications to predict specific drug-drug interactionsInteractions attributed to the combined use of LIORESAL INTRATHECAL and epidural morphine include hypotension and dyspnea.
Baclofen is used to treat muscle spasms caused by certain conditionssuch as multiple sclerosisspinal cord injury/diseaseIt works by helping to relax the muscles.
Pharmacodynamics of LIORESAL INTRATHECAL Intrathecal BolusAdult PatientsThe onset of action is generally one-half hour to one hour after an intrathecal bolusPeak spasmolytic effect is seen at approximately four hours after dosing and effects may last four to eight hoursOnsetpeak responseand duration of action may vary with individual patients depending on the dose and severity of symptoms.
LIORESAL INTRATHECAL therapy may be considered an alternative to destructive neurosurgical proceduresPrior to implantation of a device for chronic intrathecal infusion of LIORESAL INTRATHECALpatients must show a response to LIORESAL INTRATHECAL in a screening trialsee Dosage and Administration
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