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At equipotent anti-inflammatory dosesdexamethasone almost completely lacks the sodium-retaining property of hydrocortisone and closely related derivatives of hydrocortisone.
As with any printed referencethe use of particular drugsregimens and drug dosages may become out-of-date over timesince new information may have been published and become generally accepted after the latest update to this printed informationPlease keep in mind that health care professionals are fully responsible for practicing within current standardsavoiding use of outdated regimensemploying good clinical judgment in selecting drugs and/or regimensin calculating doses for individual patientsand verifying all dosage calculations.
GastrointestinalAbdominal distentionelevation in serum liver enzyme levelsusually reversible upon discontinuationhepatomegalyincreased appetitenauseapancreatitispeptic ulcer with possible perforation and hemorrhageperforation of the small and large intestineparticularly in patients with inflammatory bowel diseaseulcerative esophagitis.
Estrogens may decrease the hepatic metabolism of certain corticosteroidsthereby increasing their effect.
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