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Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemia and decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4 and 5.1
Treatment for allergies such as insect stings Tell your doctor if you are having or are going to have treatment to lower the effects of an allergy such as insect stingsdesensitisation treatmentIf you take Zestoretic while you are having this treatmentit may cause a severe allergic reaction.
Postural hypotension may become aggravated by simultaneous intake of alcoholbarbiturates or anaesthetics.
Thiazide diuretics may increase serum calcium levels due to decreased excretionIf calcium supplements or Vitamin D must be prescribedserum calcium levels should be monitored and the dose adjusted accordingly.
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