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Results from these six fixed-dosemonotherapy studies were also combined to derive a weighted average of the difference from placebo in mean change from baseline for one-hour postprandial plasma glucose levels as shown in the following figure:
Precose has been shown to change the bioavailability of digoxin when they are coadministeredwhich may require digoxin dose adjustmentSee CLINICAL PHARMACOLOGYDrug-Drug Interactions
In contrast to sulfonylureasPrecose does not enhance insulin secretionThe antihyperglycemic action of acarbose results from a competitivereversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymesPancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestinewhile the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharidestrisaccharidesand disaccharides to glucose and other monosaccharides in the brush border of the small intestineIn diabetic patientsthis enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.
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