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Selegiline is an enzyme blockerMAO inhibitorthat works by slowing the breakdown of certain natural substances in the brainneurotransmitters such as dopaminenorepinephrineand serotonin
Severe CNS toxicity associated with hyperpyrexia and death have been reported with the combination of tricyclic antidepressants and non-selective MAOIsNARDILPARNATEA similar reaction has been reported for a patient on amitriptyline and ELDEPRYLAnother patient receiving protriptyline and ELDEPRYL developed tremorsagitationand restlessness followed by unresponsiveness and death two weeks after ELDEPRYL was addedRelated adverse events including hypertensionsyncopeasystolediaphoresisseizureschanges in behavioral and mental statusand muscular rigidity have also been reported in some patients receiving ELDEPRYL and various tricyclic antidepressants.
Some medicines can cause unwanted or dangerous effects when used with EldeprylYour doctor may need to change your treatment plan if you use any of the following drugs:
ELDEPRYL is contraindicated in patients with a known hypersensitivity to this drug.
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to make sure eldepryl is safe for you, tell your doctor if you have .