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Preferred drug of choice in elderly over tricyclic antidepressants because of fewer side effects.

Since the introduction of fluoxetinesystemic reactionspossibly related to vasculitis and including lupus-like syndromehave developed in patients with rashAlthough these reactions are rarethey may be seriousinvolving the lungkidneyor liverDeath has been reported to occur in association with these systemic reactions.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotoninExamples include street drugs such as MDMAecstasyStJohn’s wortcertain antidepressantsincluding other SSRIs such as citalopram/paroxetineSNRIs such as duloxetine/venlafaxinetryptophanamong othersThe risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

As with other SSRIsdecreased weight gain has been observed in association with the use of fluoxetine in children and adolescent patientsAfter 19 weeks of treatment in a clinical trialpediatric subjects treated with fluoxetine gained an average of 1.1 cm less in height and 1.1 kg less in weight than subjects treated with placeboIn additionfluoxetine treatment was associated with a decrease in alkaline phosphatase levelsThe safety of fluoxetine treatment for pediatric patients has not been systematically assessed for chronic treatment longer than several months in durationIn particularthere are no studies that directly evaluate the longer-term effects of fluoxetine on the growthdevelopment and maturation of children and adolescent patientsThereforeheight and weight should be monitored periodically in pediatric patients receiving fluoxetinesee WARNINGS AND PRECAUTIONS

Table 2Altered Appetite and Weight Treatment Emergent Adverse ReactionsIncidence in PMDD Placebo-Controlled Clinical Trials.

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