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In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.
When administered concurrentlythe following drugs may interact with adrenal corticosteroids.
Inform the patient to keep this medication and all drugs out of the reach of children.
Patients should not be vaccinated against smallpox while on corticosteroid therapyOther immunization procedures should not be undertaken in patients who are on corticosteroidsespecially on high dosebecause of possible hazards of neurological complications and a lack of antibody response.
Adverse reactions to corticosteroids may be produced by too rapid withdrawal or by continued use of large doses.
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