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Since levodopa competes with certain amino acids for transport across the gut wallthe absorption of levodopa may be impaired in some patients on a high protein diet.

If you have trouble remembering to take your tabletsask your pharmacist for some hints.

Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopaSome patients who responded poorly to levodopa have improved on SINEMETThis is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous systemCarbidopa has not been shown to enhance the intrinsic efficacy of levodopa.

SINEMET and iron salts or multivitamins containing iron salts should be coadministered with cautionIron salts can form chelates with levodopa and carbidopa and consequently reduce the bioavailability of carbidopa and levodopa.

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because levodopa may activate a malignant melanoma, sinemet cr or half sinemet cr should not be used in patients with suspicious undiagnosed skin lesions or a history of melanoma.

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